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Practice varies considerably between different UK centers. Studies are characterized by lack of peer reviewed publication and heterogeneity in design, reporting, and analysis. There are few published data on sunitinib use in UK clinical practice. For use of RWD in the reimbursement setting, data collection and reporting will need to improve. Median progression-free survival and adverse events were generally comparable to the clinical trial outcomes, but overall survival was not.Ĭonclusion: There are few published data on sunitinib use in UK clinical practice. Practice relating to starting dose, dose modification, timing of therapy initiation, and other factors varied between centers. Results: Real world study reporting quality was generally low, making comparisons with the clinical trials difficult. Fifteen real world studies were included, 14 of which were only available as posters/presentations.
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A qualitative summary of the results and comparison to the controlled clinical trials was conducted. UK observational studies recording first- or second-line sunitinib efficacy were included. Method: Systematic review of the real world published literature was undertaken.
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This systematic review seeks to compare outcomes for sunitinib in routine UK clinical practice with the sunitinib registrational and expanded-access program clinical trials. 2Department of Medical Oncology, The Royal Marsden Hospital, London, UKīackground: Real world data (RWD) are increasingly used to inform drug reimbursement decisions, but it is unclear how well outcomes from real world studies compare to those of clinical trials.
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